Frequency: Quarterly E- ISSN: 0976-3783 P- ISSN: Online Journal IBI Factor: 4.09 Abstracted/ Indexed in: CAS database (a division of the American Chemical Society), Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, InfoBase Index, JournalRate, EBSCO Information Services
Quarterly published in print and online "Inventi Rapid: Pharm Tech" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under pharmaceutics and pharmaceutical technology. It welcomes articles pertaining to physical, chemical and biological properties of dosage forms, devices and delivery systems for drugs, vaccines and biologicals including their design, manufacture and evaluation. Special emphasis is given for articles pertaining to excipients such as surfactants and polymers and novel materials, and products for personalized medication.
Fast dissolving oral dispersible films is a new type of delivery system also known as fast dissolving or disintegrating film for the oral delivery of the drugs which came into existence in 1970�s as an alternative to conventional tablets, capsules and syrups for paediatric and geriatric patients, who experience difficulties in swallowing solid dosage forms which has both the advantages of conventional tablet and of liquid formulation. Now a days fast dissolving oral films are used over conventional tablets and capsules to increase the patient compliance. Fast dissolving oral films consists of very thin film which gets dissolved in less than one minute when placed on the tongue. These are mostly used in delivering vitamins, vaccines and drug products which are widely accepted by the consumers. The present review reveals on various fast dissolving oral dispersible films and methods used in the formulation along with the evaluation parameters and a review was performed on the various fast dissolving oral film patents....
The concepts of particle engineering and dosage form design have become dominant themes in pharmaceutical manufacturing. The need for particle size con¬trol of pharmaceuticals is becom¬ing more important as the industry attempts to formulate active phar¬maceutical ingredients (API’s) with poor aqueous solubility, which constitutes up to 40% of new chemical entities. The fundamental issue with particle size analysis is the variety of equivalent particle diameters generated by different methods, which is largely ascribable to the particle shape and particle dispersion mechanism involved. Thus, to enable selection of the most appropriate or optimal sizing technique, cross-correlation between different techniques may be required....
The present study has been aimed to prepare the diclofenac sodium tablets formulation by using banana starch and compare the banana starch and potato starch as binder, banana starch is incorporated to prevent the side effects of diclofenac like gastrointestinal problems, in addition banana starch was incorporated as binder and disintegrant which replaces normal binder used in it. Tablets prepared with potato starch were named as formulation ‘A ‘and while banana starch was in formulation ‘B’. The activity of diclofenac was not altered by banana starch verified by IR spectroscopy. The tablets were evaluated for thickness, hardness, friability, dissolution and disintegration studies. The tablet hardness, friability were generally higher with the banana starch, disintegration is slow with the banana starch tablets that indicates the sustained release of tablet and further tested for dissolution studies, which showed better release of drug. From the present study, formulation ‘B’ was found to be most effective as it decreases the side effects and the concentration of excipients....
Bi-layered tablet provide one of the important design approaches to achieve controlled delivery of different drugs with pre-defined release profiles where incompatible drugs, drugs with different indication, and same drug with different release rate can be incorporated in a single unit. Bilayered tablet can be a primary option to avoid physical and chemical incompatibilities between APIs by physical separation, and to enable the development of different drug release profiles like immediate release with extended release property. Generally the pharmacokinetic profile of active drug molecule relies on the fact that the fast release layer provide the loading dose of drug and the sustained release of drug maintain the drug concentration within therapeutic window for longer period of time. Several pharmaceutical companies are currently developing bilayered tablets for a variety of reasons like good therapeutic indication, patient compliances and conventional dosage as compare to other dosage forms. Despite their advantages, due to the use of different materials and complex geometric boundaries between the adjacent layers, the mechanical structures of this drug delivery system have become quite intricate, requiring complicated tablet architectures. This article explains why the development and production of quality bilayer tablet needs to be carried out, the advantages, disadvantages and different methods of formulation as well as study of tablet presses to overcome common bi-layer problems, such as cross-contamination between the layers, layer-separation, individual layer weight control, insufficient hardness etc. for bilayer tablets....
A fast-dissolving drug delivery system, in most cases, is a tablet that dissolves or disintrigrants in the oral cavity without the need of water or chewing. Most fast-dissolving delivery system films must include substances to mask the taste of the active ingredient. This masked active ingredient is then swallowed by the patient''s saliva along with the soluble and insoluble excipients. These are also called melt-in-mouth tablets, repimelts, porous tablets, oro-dispersible, quick dissolving or rapid disintegrating tablets....
A 505(b)(2) is provision to seek the regulatory approval without conducting the studies or taking right of reference for new products. There are three regulatory pathways to get the marketing approval for new products in federal register of drug products; 505 (b)(1)New drug application, 505 (b)(2) Hybrid NDA and 505 (j) for ANDA. 505(b)(2) provision has made to avoid the duplication of study, reduce the development time and cost. Topical drug development is popular now days and most of the companies are diverted to topical formulation development. The topical drug development for 505 (b)(2) is useful for long term business, get exclusive marketing rights and get easy entry into market with branded product. A 505(b)(2) involves the no or minimum nonclinical and clinical studies to prove safety and effectiveness of the new products. The choice of RLD Selection and excipients selection also minimizes the number studies required. In last 5 years on an average USFDA has approved 505(b)(2) products and majority are new dosage forms. Typical examples from different filing strategy are discussed related to Topical and transdermal products....
Emulgels are emulsion system, either of the oil-in-water or water in-oil type, which are gelled by mixing with a gelling agent. Both oil-in-water and water-in-oil emulsions are extensively used for their therapeutic properties and as vehicles to deliver various drugs to the skin. Emulsions possess a certain degree of elegance and are easily washed off whenever desired. In addition, the formulator can control the viscosity, appearance, and degree of greasiness of cosmetic or dermatological emulsions. Gels for dermatological use have several favorable properties such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, non staining, compatible with several excipients, and water-soluble or miscible. Gellifying the emulsion increases the viscosity of the emulsion and also its stability. The emulsion-based gel have great potential for topical drug delivery....
Among novel drug delivery system buccal mucoadhesive system offers certain unique advantages for the drugs which cannot be easily administered by oral or intravenous route due to their ability to adhere and remain on the oral mucosa to release their drug content gradually. Mucoadhesion is the process where polymers attached to biological substrate, synthetic or natural molecules, to mucus epithelial surface. Buccal mucoadhesive film improve the therapeutic effect of drugs by increasing absorption of drugs through oral mucosa and mucoadhesive polymers increases the contact time with the mucus membranes. This article extensively reviews the brief description of the anatomical structure of oral mucosa, mechanism of drug absorption, aspects of dosage form design, mucoadhesion and mucoadhesive polymers followed by permeation enhancer with its mechanism of actions....
Fast dissolving oral films are the advanced form of dosage form due to more flexibility and comfort as it improve the efficacy of APIs by dissolving within oral cavity after the get in touch with less saliva as compared to fast dissolving tablets, without chewing and no necessitate of water for administration. The FDOFs place as a substitute in the market due to the consumer’s fondness for a fast dissolving product over conventional tablets/capsules. The oral thin-film technology is still in the foundation stages and has intense future in front because it fulfils all the need of patients. These films have a potential to deliver the drug systemically through intragastric, sublingual or buccal route of administration. The present review provides an account of various formulation considerations, method of preparation, formulation technologies and various patents available in US country....
Mouth Dissolving Film is the promising approach for most of the drug delivery. MDF�s is the newer type for drug delivery through which many types of drugs such Anti-Hypertensive, Cough-Cold remedies and many more drugs can be delivered. MDF�s are generally consisting of different synthetic as well as natural polymers. Present review enlightens the advantages of MDF such as it is more preferable in pediatric and geriatric patients. As it does not require any liquid supplements to take with it, it increases the patient compliance and so more suitable over other conventional dosage forms. This review describes the methods of preparation and formulation considerations for effective MDF formulation development. It also includes the quality control evaluation for the same....
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